7 Laufende Doktorarbeiten
6 Abgeschlossene Doktorarbeiten der letzten 5 Jahre (2017 – 2021)
15 Abgeschlossene Habilitationen der letzten 10 Jahre (2012 – 2021)
2022
- Dmitry Bobylev, Mathias Wilhelmi, Skadi Lau, Melanie Klingenberg, Markus Mlinaric, Elena Petená, Florian Helms, Thomas Hassel, Axel Haverich, Alexander Horke, Ulrike Böer. Pressure-compacted and spider silk reinforced fibrin demonstrates sufficient biomechanical stability as cardiac patch in vitro. J Biomater Appl. 2022 Jan;36(6):1126-1136. doi: 10.1177/08853282211046800.
- Koop F, Strauß S, Peck CT, Aper T, Wilhelmi M, Hartmann C, Hegermann J, Schipke J, Vogt PM, Bucan V. Preliminary application of native Nephila edulis spider silk and fibrin implant causes granulomatous foreign body reaction in vivo in rat's spinal cord PLoS One. 2022 Mar 14;17(3):e0264486. doi: 10.1371/journal.pone.0264486
2021
- Florian Helms, Axel Haverich, Mathias Wilhelmi, Ulrike Böer. Establishment of a Modular Hemodynamic Simulator for Accurate In Vitro Simulation of Physiological and Pathological Pressure Waveforms in Native and Bioartificial Blood Vessels. Cardiovasc Eng Technol. 2021 Sep 23. doi: 10.1007/s13239-021-00577-0.
- Die Arbeit wurde mit dem Günther Haenisch Preis der Vereinigung Norddeutscher Chirurgen e.V. ausgezeichnet
- Grosse GM, Derda AA, Stauss RD, Neubert L, Jonigk DD, Kühnel MP, Gabriel MM, Schuppner R, Wilhelmi M, Bär C, Bauersachs J, Schrimpf C, Thum T, Weissenborn K. Circulating microRNAs in symptomatic and asymptomatic carotid stenosis“ Front Neurol. 2021 Nov 24;12:755827. doi: 10.3389/fneur.2021.755827.
- Florian Helms, Axel Haverich, Ulrike Böer, Mathias Wilhelmi. Transluminal compression increases mechanical stability, stiffness and endothelialization capacity of fibrin-based bioartificial blood vessels. Mech Behav Biomed Mater. 2021 Dec;124:104835. doi: 10.1016/j.jmbbm.2021.104835.
- Zippusch S, Besecke KFW, Helms F, Klingenberg M, Lyons A, Behrens P, Haverich A, Wilhelmi M, Ehlert N, Böer U. Chemically induced hypoxia by dimethyloxalylglycine (DMOG)-loaded nanoporous silica nanoparticles supports endothelial tube formation by sustained VEGF release from adipose tissue-derived stem cells. Regen Biomater. 2021 Aug 14;8(5):rbab039. doi: 10.1093/rb/rbab039. Die Arbeit wurde mit dem Posterpreis der Deutschen Gesellschaft für Gefäßchirurgie – Gefäßmedizin e.V. ausgezeichnet
- Saad Rustum, Julia Neuser, Jan Dieter Schmitto, Thomas Aper, Jasmin Sarah Hanke, Axel Haverich, Mathias Wilhelmi. Vascular procedures in patients with left ventricular assist devices: single-center experience. Indian Journal of Thoracic and Cardiovascular Surgery 2021. doi.org/10.1007/s12055-021-01192-3
- Zippusch S, Helms F, Lau S, Klingenberg M, Schrimpf C, Haverich A, Wilhelmi M, Böer U. Perfusion promotes endothelialized pore formation in high concentration fibrin gels otherwise unsuitable for tube development. Int J Artif Organs. 2021 Feb;44(2):130-138. doi: 10.1177/0391398820936700. Epub 2020 Jul 2.PMID: 32611278
- Helms F, Lau S, Aper T, Zippusch S, Klingenberg M, Haverich A, Wilhelmi M, Böer U. A 3-Layered Bioartificial Blood Vessel with Physiological Wall Architecture Generated by Mechanical Stimulation. Ann Biomed Eng. 2021 Jan 22. doi: 10.1007/s10439-021-02728-9. Online ahead of print.PMID: 33483842
2020
- Stauss RD, Grosse GM, Neubert L, Falk CS, Jonigk D, Kühnel MP, Gabriel MM, Schuppner R, Lichtinghagen R, Wilhelmi M, Weissenborn K, Schrimpf C. Distinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis. Sci Rep. 2020 Dec 15;10(1):21963. doi: 10.1038/s41598-020-789418.PMID: 33319833
- Debus ES, Gross-Fengels W, Heidemann F, Mahlmann A, Muhl E, Pfister K, Roth S, Stroszczynski C, Walther A, Weiss N, Wilhelmi M, Grundmann RT. Webinar zur S3-Leitlinie Screening, Diagnostik, Therapie und Nachsorge des Bauchaortenaneurysmas. Chirurg. 2020 Feb;91(2):167-168. doi: 10.1007/s00104-020-01116-8.
- Schrimpf C, Ziesing S, Michelmann P, Rustum S, Teebken OE, Haverich A, Wilhelmi M. Conventional culture diagnostics vs. multiplex PCR for the detection of causative agents of vascular graft infections - results of a single centre observational pilot study. Vasa. 2020 Jan;49(1):43-49. doi: 10.1024/0301-1526/a000827. Epub 2019 Nov 22.
- Helms F, Lau S, Klingenberg M, Aper T, Haverich A, Wilhelmi M, Böer U. Complete Myogenic Differentiation of Adipogenic Stem Cells Requires Both Biochemical and Mechanical Stimulation. Ann Biomed Eng. 2020 Mar;48(3):913-926. doi: 10.1007/s10439-019-02234-z. Epub 2019 Feb 27.
2019
Lau S, Klingenberg M, Mrugalla A, Helms F, Sedding D, Haverich A, Wilhelmi M, Böer U. Biochemical Myogenic Differentiation of Adipogenic Stem Cells Is Donor Dependent and Requires Sound Characterization. Tissue Eng Part A. 2019 Jul;25(13-14):936-948. doi: 10.1089/ten.TEA.2018.0172. Epub 2019 Jun 14.
2018
- Jeinsen N, Mägel L, Jonigk D, Klingenberg M, Haverich A, Wilhelmi M, Böer U. Biocompatibility of Intensified Decellularized Equine Carotid Arteries in a Rat Subcutaneous Implantation Model and in a Human In Vitro Model. Tissue Eng Part A. 2018 Feb;24(3-4):310-321. doi: 10.1089/ten.TEA.2016.0542. Epub 2017 Jun 29.
- Aper T, Wilhelmi M, Boer U, Lau S, Benecke N, Hilfiker A, Haverich A. Dehydration improves biomechanical strength of bioartificial vascular graft material and allows its long-term storage. Innov Surg Sci. 2018 Jul 23;3(3):215-224. doi: 10.1515/iss-2018-0017. eCollection 2018 Sep.
- Grosse GM, Bascuñana P, Schulz-Schaeffer WJ, Teebken OE, Wilhelmi M, Worthmann H, Ross TL, Wester HJ, Kropf S, Derlin T, Bengel FM, Bankstahl JP, Weissenborn K. Targeting Chemokine Receptor CXCR4 and Translocator Protein for Characterization of High-Risk Plaque in Carotid Stenosis Ex Vivo. Stroke. 2018 Aug;49(8):1988-1991. doi: 10.1161/STROKEAHA.118.021070.
- Lau S, Eicke D, Carvalho Oliveira M, Wiegmann B, Schrimpf C, Haverich A, Blasczyk R, Wilhelmi M, Figueiredo C, Böer U. Low Immunogenic Endothelial Cells Maintain Morphological and Functional Properties Required for Vascular Tissue Engineering. Tissue Eng Part A. 2018 Mar;24(5-6):432-447. doi: 10.1089/ten.TEA.2016.0541. Epub 2017 Dec 19.
2017
- Weimar C, Bilbilis K, Rekowski J, Holst T, Beyersdorf F, Breuer M, Dahm M, Diegeler A, Kowalski A, Martens S, Mohr FW, Ondrášek J, Reiter B, Roth P, Seipelt R, Siggelkow M, Steinhoff G, Moritz A, Wilhelmi M, Wimmer-Greinecker G, Diener HC, Jakob H, Ose C, Scherag A, Knipp SC; CABACS Trial Investigators. Safety of Simultaneous Coronary Artery Bypass Grafting and Carotid Endarterectomy Versus Isolated Coronary Artery Bypass Grafting: A Randomized Clinical Trial. Stroke. 2017 Oct;48(10):2769-2775. doi: 10.1161/STROKEAHA.117.017570. Epub 2017 Sep 15.
- Schrimpf C, Koppen T, Duffield JS, Böer U, David S, Ziegler W, Haverich A, Teebken OE, Wilhelmi M. TIMP3 is Regulated by Pericytes upon Shear Stress Detection Leading to a Modified Endothelial Cell Response. Eur J Vasc Endovasc Surg. 2017 Oct;54(4):524-533. doi: 10.1016/j.ejvs.2017.07.002. Epub 2017 Aug 12.
- Rustum S, Beckmann E, Wilhelmi M, Krueger H, Kaufeld T, Umminger J, Haverich A, Martens A, Shrestha M. Is the frozen elephant trunk procedure superior to the conventional elephant trunk procedure for completion of the second stage? Eur J Cardiothorac Surg. 2017 Oct 1;52(4):725-732. doi: 10.1093/ejcts/ezx199.
- Kolster M, Wilhelmi M, Schrimpf C, Hilfiker A, Haverich A, Aper T. Outgrowing endothelial and smooth muscle cells for tissue engineering approaches. J Tissue Eng. 2017 Mar 15;8:2041731417698852. doi: 10.1177/2041731417698852
- Böer U, Buettner FF, Schridde A, Klingenberg M, Sarikouch S, Haverich A, Wilhelmi M. Antibody fprmation towards porcine tissue in patients implanted with crosslinked heart valves is directed to antigenic tissueαα proteins and αGal epitopes and is reduced in healthy vegetarian subjects. Xenotransplantation. 2017 Jan 18.
- Hinrichs JB, Murray T, Akin M, Lee M, Brehm MU, Wilhelmi M, Wacker FK, Rodt T. Evaluation of a novel 2D perfusion angiography technique independent of pump injections for assessment of interventional treatment of peripheral vascular disease. Int J Cardiovasc Imaging. 2017 Mar;33(3):295-301