DGG Mannequin

Department of Vascular Surgery – Vascular and Endovascular Surgery, University Hospital Cologne (AöR)

Research location

Department of Vascular Surgery – Vascular and Endovascular Surgery, University Hospital Cologne (AöR)
Professor Bernhard Dorweiler

Research

Head of the Research Programme:

Experimental Laboratory: PD Dr W. Ahmad

Head of the Wound Centre: Dr T. Trinh

Head of the Study Centre: Mr M. Filus

Location
Kerpener Straße 62
50937 Köln

Icon Ausstattung

Equipment

  • Basic Research Laboratory 3D Printing Laboratory
  • Clinical Trials Centre
  • Study nurse (2)
  • Biomaterials Bank Tissue and Serum

About collaboration:

  • Basic molecular biology laboratory
  • Basic Biomechanics Laboratory
  • Small animal laboratory
  • Large Animal Facility
Icon Methoden

Methods

  • Histology & immunohistochemistry, including image documentation and semi-quantitative analysis
  • Cell culture
  • 3D printing laboratory (including multi-material (flexible) and multi-colour printing)

About collaboration:

  • Imaging (CLSM)
  • Proteomics
  • Lipidomics
  • Animal testing (including large animals)
  • Biomechanical testing
Icon Personal

Staff

  • 7 doctors with research projects
  • 3 teaching assistants
  • 6 PhD students

Research focus areas

  • Vascular tissue bank with projects/research questions on vascular inflammation and apoptosis
  • 3D laboratory (patient-specific modelling, production of surgical, training and simulation phantoms)
  • Clinical databases with research questions on remodelling following TBAD, implantation behaviour following endovascular aneurysm treatment (FEVAR/BEVAR/IBD), and long-term outcomes following infrainguinal open and interventional reconstructions
  • MeSH (Medical Subject Headings): Aortic aneurysm, Aortic diseases, 3D printing, Inflammatory mediators, Apoptosis, Endovascular procedures, Simulation training

Contact person

Prof. Dr. med. Bernhard Dorweiler

Send email

PD Dr. med. Wael Ahmad

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Publications

  1. Cai B, Thorp EB, Doran AC, Sansbury BE, Daemen MJ, Dorweiler B, Spite M, Fredman G, Tabas I. MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis. J Clin Invest. 1 February 2017;127(2):564-568
  2. Dorweiler B, Boedecker C, Dünschede F, Vahl CF, Youssef M. 3D analysis of component stability of the Nellix® endovascular aneurysm sealing (EVAS) technology following treatment of infrarenal abdominal aortic aneurysms. J Endovasc Ther. 2017 Apr;24(2):201-209
  3. Grechowa I, Horke S, Wallrath A, Vahl CF, Dorweiler B. Human neutrophil elastase induces endothelial cell apoptosis by activating the PERK-CHOP branch of the unfolded protein response. FASEB J 2017 Sep;31(9):3868-3881
  4. Chen J, Li J, Yiu JHC, Lam JKW, Wong CM, Dorweiler B, Xu A, Woo CW. TRIF-dependent Toll-like receptor signalling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis. Sci Signal. 8 August 2017;10(491). pii: eaal3336. doi: 10.1126/scisignal.aal3336
  5. Doran AC, Ozcan L, Cai B, Zheng Z, Fredman G, Rymond CC, Dorweiler B, Sluimer JC, Hsieh J, Kuriakose G, Tall AR, Tabas I. CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis. J Clin Invest. 1 November 2017;127(11):4075-4089
  6. Ghazy A, Chaban R, Vahl CF, Dorweiler B. Development and evaluation of 3D-printed models of the human tracheobronchial system for training in flexible bronchoscopy. Interact Cardiovasc Thorac Surg. 1 January 2019;28(1):137-143
  7. Krumb H, Hofmann S, Kügler D, Ghazy A, Dorweiler B, Bredemann J, Schmitt R, Sakas G, Mukhopadhyay A. Leveraging spatial uncertainty for online error compensation in EMT. Int J Comput Assist Radiol Surg. June 2020;15(6):1043-1051. doi: 10.1007/s11548-020-02189
  8. Yiu JHC, Chan KS, Cheung J, Li J, Liu Y, Wang Y, Fung WLW, Cai J, Cheung SW, Dorweiler B, Wan EYF, Tso P, Xu A, Woo CWH. Gut Microbiota-Associated Activation of TLR5 Induces Apolipoprotein A1 Production in the Liver. Circ Res. 21 August 2020. doi: 10.1161/CIRCRESAHA.120.317362
  9. Riedle H, Chaban R, Ghazy A, Piplat C, Dorweiler B, Franke J. Experimental determination of the suture behaviour of aortic tissue in comparison to 3D-printed silicone modelling material. J Mech Behav Biomed Mater. 25 August 2020;112:104033. doi: 10.1016/j.jmbbm.2020.104033.
  10. Riedle H, Ghazy A, Seufert A, Seitz V, Dorweiler B, Franke J. Generic design of an anatomical heart model optimised for additive manufacturing with silicone. Rapid Prototyping Journal 2020 DOI 10.1108/RPJ-11-2019-0283
  11. Kasikara C, Schilperoort M, Gerlach BD, Xue C, Wang X, Zheng Z, Kuriakose G, Dorweiler B, Zhang H, Fredman G, Saleheen D, Reilly MP, Tabas I. Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis. J Clin Invest. 25 February 2021:145275. doi: 10.1172/JCI145275.
  12. Dorweiler B, Baqué PE, Chaban R, Ghazy A, Salem O. Quality Control in 3D Printing: Accuracy Analysis of 3D-Printed Models of Patient-Specific Anatomy. Materials (Basel). 21 February 2021;14(4):1021. doi: 10.3390/ma14041021.
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