DGG Mannequin

Department of Vascular and Endovascular Surgery, Heidelberg University Hospital

Research location

Department of Vascular and Endovascular Surgery, Heidelberg University Hospital
Director: Prof. Dittmar Böckler, MD

Research

Translational Vascular Surgery Section

Head: PD Dr Andreas Peters

Basic Research

Head: Prof. Dr. rer. nat. Susanne Dihlmann

Clinical Trials Centre

Head: PD Dr Philipp Erhart

Tissue Bank

Head: PD Dr Andreas Peters

Location
Im Neuenheimer Feld 420
69120 Heidelberg

Icon Ausstattung

Equipment

  • Molecular Biology/Cell Biology Laboratory (S1 and S2)
  • Clinical Trials Centre
  • Genetic Consultation
  • Tissue Bank
Icon Methoden

Methods

  • Histology, immunohistochemistry, immunofluorescence of tissue or cells
  • Cell culture of primary vascular wall cells
  • Analysis of signal transduction mechanisms in vitro
  • DNA, RNA and protein analyses
  • Animal experiments (mouse model for aortic aneurysm)
Icon Personal

Staff

  • Head of Laboratory
  • PhD students (cand. med.)
  • Biology laboratory assistant
  • Study nurse

Research focus areas

Clinical:

  • Healthcare research on AAA and PAD
  • AI/Mixed Reality in patient education
  • Teaching and learning research

Fundamentals:    

  • Cellular pathomechanisms of aortic diseases
  • Oxidative stress and inflammation in vascular endothelial cells

Translational:

  • Genetic causes of aortic diseases
  • Genetic causes of multiple aneurysms

Contact person

PD Dr. med. A. Peters

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Collaborations

On campus:

  • SFB 1118: Reactive metabolites as a cause of diabetic complications (Principal Investigator: Prof. Dr. med. S. Herzig),
  • Subproject A04: The significance of the enzymatic regulation of methylglyoxal metabolism in diabetic neuropathy (Head: Dr Th. Fleming) 

Events and network

  • PhD Seminar: ‘Current Issues in Molecular, Experimental and Clinical Research’
  • Heidelberg Hot Topic
  • Member of the Basic Research in Vascular Medicine Network

Publications

  1. Wortmann, M.; Peters, A.S.; Erhart, P.; Korfer, D.; Bockler, D.; Dihlmann, S. Inflammasomes in the Pathophysiology of Aortic Disease. Cells 2021, 10, doi:10.3390/cells10092433.
  2. Wortmann, M.; Arshad, M.; Peters, A.S.; Hakimi, M.; Bockler, D.; Dihlmann, S. The C57Bl/6J mouse strain is more susceptible to angiotensin II-induced aortic aneurysm formation than C57Bl/6N. Atherosclerosis 2021, 318, 8–13, doi:10.1016/j.atherosclerosis.2020.11.032.
  3. Wortmann, M.; Arshad, M.; Hakimi, M.; Bockler, D.; Dihlmann, S. Deficiency in Aim2 affects viability and calcification of vascular smooth muscle cells from murine aortas and angiotensin-II-induced aortic aneurysms. Mol Med 2020, 26, 87, doi:10.1186/s10020-020-00212-z.
  4. Hakimi, M.; Peters, A.; Becker, A.; Bockler, D.; Dihlmann, S. Inflammation-related induction of absent in melanoma 2 (AIM2) in vascular cells and atherosclerotic lesions suggests a role in vascular pathogenesis. J Vasc Surg 2014, 59, 794–803 e792, doi:10.1016/j.jvs.2013.03.048.
  5. Dihlmann, S.; Erhart, P.; Mehrabi, A.; Nickkholgh, A.; Lasitschka, F.; Bockler, D.; Hakimi, M. Increased expression and activation of absent in melanoma 2 inflammasome components in lymphocytic infiltrates of abdominal aortic aneurysms. Mol Med 2014, 20, 230–237, doi:10.2119/molmed.2013.00162
  6. Erhart P, Gieldon L, Ante M, Körfer D, Strom T, Grond-Ginsbach C, Böckler D. Acute Stanford type B aortic dissection—who benefits from genetic testing? J Thorac Dis 2020, 12(11):6806–6812. doi: 10.21037/jtd-20-2421
  7. Hatzl J, Batenburg MVB, Yeung KK, Fioole B, Verhoeven E, Lauwers G, Kölbel T, Wever JJ, Scheinert D, Van den Eynde W, Rouhani G, Mees BME, Vermassen F, Schelzig H, Cuypers PWM, Böckler D; Zephyr study group collaborators. Thirty-day Results from the ZEPHYR Registry: Outcomes of EVAR Using the Zenith Alpha™ Abdominal Endovascular Graft for the Treatment of AAA in 347 Patients. Ann Vasc Surg 2021, Online ahead of print.
  8. Meisenbacher K, Böckler D, Geisbüsch P, Hank T, Bischoff MS. Preliminary results of spot-stent grafting in Stanford type B aortic dissection and intramural haematoma. Eur J Cardiothorac Surg 2020, 58(5):932-939. doi: 10.1093/ejcts/ezaa198.
  9. Bischoff MS, Meisenbacher K, Wehrmeister M, Böckler D, Kotelis D. Treatment indications for and outcome of endovascular repair of type B intramural aortic haematoma. J Vasc Surg 2016, 64(6):1569-1579.e2. doi: 10.1016/j.jvs.2016.05.078.
  10. 1Bischoff MS, Geisbüsch P, Peters AS, Hyhlik-Dürr A, Böckler D. Penetrating aortic ulcer: defining risks and therapeutic strategies. Herz 2011, 36(6):498-504. doi: 10.1007/s00059-011-3513-9.
     
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