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Klinikum der Ludwig-Maximilians-Universität München

The LMU University Hospital

Research location

The LMU University Hospital
Prof. Dr Nikolaos Tsilimparis

Research

Prof. Dr Nikolaos Tsilimparis,
Dr Nikolaos Konstantinou,
Dr Jan Stana
 

Location
Marchioninistrasse 15
81377 München

Icon Ausstattung

Equipment

  • Basic Research Laboratory: Biomechanics
  • Clinical Trials Centre: 2 study nurses
  • Biomaterials bank: tissue, serum
Icon Methoden

Methods

Methods 1 

  • 3D printing (K)
  • Biobank (K)
  • 4-D MRI (K)
  • AI-assisted CT analyses (E)
  • Flow-loop for circulatory simulation (K)
     
Icon Personal

Staff

  • 7 doctors with research projects
  • 9 PhD students
  • 1 PhD
  • 1 scientist
     

Research focus areas

Focus Area I: Aortic Surgery

Clinical: Mono- and multicentre analysis (prospective, retrospective, registry) of aortic surgical procedures, focusing on aortic arch pathologies and thoracoabdominal aortic diseases  

SPONSORED studies:

PAPAartis – Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging with “Minimally-Invasive Staged Segmental Artery Coil-Embolisation”. A Randomised Controlled Multicentre Trial

BeGraft+ Stent as a bridging stent in FEVAR – Prospective, multicentre, single-arm physician-initiated trial to evaluate the safety and performance of the BeGraft+ Stent Graft System as a bridging stent in FEVAR for complex aortic aneurysms

BeGraft+ Stent as a bridging stent in FEVAR – Prospective, multicentre, single-arm physician-initiated trial to evaluate the safety and performance of the BeGraft+ Stent Graft System as a bridging stent in FEVAR for complex aortic aneurysms

ZTA Post-Market Data Collection – A Post-Market Clinical Follow-Up Study on

Cook Medical Zenith® AlphaTM Thoracic Endovascular Grafts (retrospective and prospective single-arm, observational clinical study involving the extraction of data from the medical records of patients in whom ZTA was used)

EADC (Cook’s European Aortic Data Collection) – Post-market, prospective clinical study

SHOCKWAVE TEVAR - International multi-centre study to confirm the safety and performance of the Shockwave™ Peripheral Intravascular Lithotripsy Balloon for advanced endovascular aortic repair. A prospective, multi-centre, international, observational, single-arm cohort study

Further studies and projects:

Aortic Registry – Acquisition and collection of data on subjects who underwent aortic surgery

RESCOUT – multicentre registry - Munich Valsalva Technique. International retrospective and prospective data collection

iPAUER – Infrarenal Penetrating Aortic Ulcers Treatment Multicentre Registry Study. International retrospective and prospective data collection

FEORA – FEVAR vs Open Repair in Para/Juxtarenal Aortic Aneurysm. Multicentre retrospective data collection

FACTUAL – Fate of the Celiac Trunk After Complex Endovascular Repair. Retrospective data analysis regarding the patency of the CT after F/BEVAR

LIMBUS – Iliac Limb Occlusion in Standard EVAR with Zenith Alpha Abdominal. A retrospective, international multicentre study

SCAR - Spinal Cord Ischaemia and Chronic Back Pain Following Thoracoabdominal Endovascular Aortic Repair. A retrospective single-centre study

Outcomes of Fenestrated and Branched Custom-Made and Off-The-Shelf Endografts for the Left Subclavian Artery – A Systematic Review and Meta-Analysis

Inner Branches for Complex Aortic Aneurysms – Comparison of Inner Versus Outer Branches in the Treatment of Complex Aortic Aneurysms. Multicentre, retrospective observational study

Focus Area II: Treatment of peripheral arterial disease

Clinical: Outcome analyses following treatment with different thrombectomy devices

SPONSORED STUDIES:

ELEGANCE - Drug-ELuting REGistry: ReAl-World Treatment of LesioNs in the Peripheral VasCulaturE. A global prospective, non-randomised, open-label, multi-centre registry to collect real-world data, including health economic data, to support the use of commercially available drug-eluting BSC devices for the treatment of lesions located in the peripheral vasculature

SHOCKWAVE - Physician-Initiated PMCF Trial Investigating Shockwave Intravascular Lithotripsy and a Drug-Eluting Vascular Stent System Deployment for Heavily Calcified Femoropopliteal 

disease. A prospective, multicentre, controlled, post-market.

SUCCESS PTA Study – SELUTION, Safety, Efficacy, Health Economics & PROMs. This study aims to prospectively collect data on the use of SELUTION SLR DEB in order to generate post-market clinical follow-up (PMCF) data to demonstrate safety and efficacy in an all-comers population of PAD patients

Focus Area III: Carotid Surgery

Clinical: Detection of new-onset strokes during treatment of complex aortic diseases (fenTEVAR, BEVAR)

Prediction of clamping ischaemia during carotid surgery (in collaboration with the Department of Neurosurgery)

Participation in the drafting and formulation of national (S3) and international guidelines (European Society for Vascular Surgery)

Supraregional stroke research via NEVAS (Neurovascular Centre of South-West Bavaria) following the establishment of a neurovascular centre in 2023

Contact person

Portrait Nikolaos Tsilimparis

Prof. Dr. med. Nikolaos Tsilimparis

Send email
Portrait Jan Stana

Dr. Jan Stana

Send email
Portrait Nikolaos Konstantinou

Dr. med. Nikolaos Konstantinou

Send email

Collaborations

On campus:

Department of Cardiac Surgery – Interdisciplinary collaboration within the LMU Aortic Centre 

Angiology and Radiology – Interdisciplinary collaboration at the Vascular Centre for peripheral arterial disease (PAD), malformations and peripheral aneurysms

Institute for Diagnostic and Interventional Neuroradiology – Collaboration in the treatment of supra-aortic vessels

Visceral and Transplant Surgery – Interdisciplinary collaboration on chronic wounds and mesenteric ischaemia

Department of Dermatology – Joint consultations for venous diseases and chronic wounds

Shunt Centre with Nephrology

Interregional: 

TU Graz IBIOSYS Institute of Biomechanics, Graz University of Technology, Graz, Austria

Events and network

Events and Networking:

  • Munich Vascular Symposium
  • ESVS Workshop
  • Other Endovascular Workshops (TAAA, BAA)

Publications

Current PhD theses: 10

Doctoral theses completed in the last 5 years (2017–2021): 4

Habilitations completed in the last 10 years (2012–2021): 2

Key publications: optionally 5–10 key publications; alternatively, PubMed (or Scopus) links for research-active staff

  1. European Multicentric Experience With Fenestrated-branched Endovascular Stent Grafting After Previous Failed Infrarenal Aortic Repair: The EU-FBENDO-FAIL Registry. Budtz-Lilly J,  D'Oria M, Gallitto E, Bertoglio L, Kölbel T, Lindström D, Dias N, Lundberg G, Böckler D, Parlani G, Antonello M, Veraldi GF, Tsilimparis N, Kotelis D, Dueppers P,  Tinelli G, Ippoliti A, Spath P, Logiacco A, Schurink GWH, Chiesa R, Grandi A, Panuccio G, Rohlffs F, Wanhainen A, Mani K, Karelis A, Sonesson B, Jonsson M,  Bresler AM, Simonte G, Isernia G, Xodo A, Mezzetto L, Mastrorilli D, Prendes CF, Chaikouni B, Zimmermann A, Lepidi S, Gargiulo M, Mees B, Unosson J // Journal: Ann Surg, IF: 9
  2. Editor’s Choice – European Society for Vascular Surgery (ESVS) 2023 Clinical Practice Guidelines on the Management of Atherosclerotic Carotid and Vertebral Artery Disease. Naylor R, Rantner B, Ancetti S, de Borst GJ, De Carlo M,  Halliday A, Kakkos SK, Markus HS, McCabe DJH, Sillesen H, van den Berg JC, Vega de Ceniga M, Venermo MA, Vermassen FEG, ESVS Guidelines Committee , Antoniou GA, Bastos Goncalves F, Bjorck M, Chakfe N, Coscas R,  Dias NV, Dick F, Hinchliffe RJ, Kolh P, Koncar IB, Lindholt JS, Mees BME, Resch TA, Trimarchi S, Tulamo R, Twine CP, Wanhainen A, Document Reviewers , Bellmunt-Montoya S, Bulbulia R,  Darling RC, Eckstein HH, Giannoukas A, Koelemay MJW, Lindström D, Schermerhorn M, Stone DH // Journal: Eur J Vasc Endovasc Surg, IF: 5.7
  3. Endovascular Versus Surgical Treatment for All Comer Patients With Prosthetic Bypass Graft Occlusion: The Multicentre ENSUPRO Study. Korosoglou G, Torsello G, Saratzis A, Isernia G, Kontopodis N, González TM, Jacobs K, Van Herzeele I, Zayed H, Stavroulakis K, ENSUPRO Collaborative // Journal: Eur J Vasc Endovasc Surg, IF: 5.7
  4. Editor's Choice - RANDOMisation Screening for Drug-coated or Drug-eluting Device Randomised Trials Among Patients Undergoing Endovascular Femoropopliteal Procedures (RANDOM-STOP study). Stavroulakis K, Katsogridakis E, Torsello G, Zayed H, van Herzeele I, Coscas R, Nasr B, Gonzalez TM, Troisi N, Saratzis A, RANDOM-STOP group // Journal: Eur J Vasc Endovasc Surg, IF: 5.7
  5. Outcomes of Elective and Non-elective Fenestrated-branched Endovascular Aortic Repair for the Treatment of Thoracoabdominal Aortic Aneurysms. Dias-Neto M, Vacirca A, Huang Y, Baghbani-Oskouei A, Jakimowicz T, Mendes BC, Kolbel T, Sobocinski J,  Bertoglio L, Mees B, Gargiulo M, Dias N, Schanzer A, Gasper W, Beck AW, Farber MA, Mani K, Timaran C, Schneider DB, Pedro LM, Tsilimparis N, Haulon S, Sweet MP, Ferreira E, Eagleton M,  Yeung KK, Khashram M, Jama K, Panuccio G, Rohlffs F, Mesnard T, Chiesa R, Kahlberg A, Schurink GW, Lemmens C, Gallitto E, Faggioli G, Karelis A, Parodi E, Gomes V, Wanhainen A, Habib M,  Colon JP, Pavarino F, Baig MS, Gouveia E Melo REC, Crawford S, Zettervall SL, Garcia R, Ribeiro T,  Alves G, Gonçalves FB, Kappe KO, Mariko van Knippenberg SE, Tran BL, Gormley S, Oderich GS, International Multicenter Aortic Research Group // Journal: Ann Surg, IF: 9
  6. Multicentre Study on Physician-Modified Endografts for Thoracoabdominal and Complex Abdominal Aortic Aneurysm Repair. Tsilimparis N, Gouveia E Melo R, Tenorio ER, Scali S, Mendes B, Han S, Schermerhorn M, Adam DJ, Malas MB, Farber M, Kölbel T, Starnes B, Joseph G, Branzan D, Cochennec F, Timaran C, Bertoglio L, Cieri E, Mendes Pedro L, Verzini F, Beck AW, Chait J, Pyun A, Magee GA, Swerdlow N, Juszczak M, Barleben A, Patel R, Gomes VC, Panuccio G, Sweet MP, Zettervall SL, Becquemin JP, Canonge J, Porras-Colón J, Dias-Neto M, Giordano A, Oderich GS. // Journal: Circulation, IF: 35
  7. Editor's Choice -- European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto-Iliac Artery Aneurysms Wanhainen A, Van Herzeele I, Bastos Goncalves F, Bellmunt Montoya S, Berard X, Boyle JR, D'Oria M, Prendes CF, Karkos CD, Kazimierczak A, Koelemay MJW, Kölbel T, Mani K, Melissano G, Powell JT, Trimarchi S, Tsilimparis N; ESVS Guidelines Committee; Antoniou GA, Björck M, Coscas R, Dias NV, Kolh P, Lepidi S, Mees BME, Resch TA, Ricco JB, Tulamo R, Twine CP; Document Reviewers; Branzan D, Cheng SWK, Dalman RL, Dick F, Golledge J, Haulon S, van Herwaarden JA, Ilic NS, Jawien A, Mastracci TM, Oderich GS, Verzini F, Yeung KK. // Journal: Cardiovasc Res, IF: 10.8
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