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Vascular and Endovascular Surgery, Frankfurt University Hospital

Research location

Vascular and Endovascular Surgery, Frankfurt University Hospital
Head: Prof. Kyriakos Oikonomou, MD

Research

Head of the Research Programme

Contact person: Prof. Kyriakos Oikonomou, MD

  Subject area:

  • Endovascular procedures, specialising in aortic surgery
  • Patient-specific endoprostheses
  • Basic and translational research into aneurysmal diseases
  • Basic research into vascular ageing                                                                     

Dr Wojciech Derwich, MHBA

Area of expertise:

  • Aortic biomechanics

Location
Theodor-Stern-Kai 7
60590 Frankfurt am Main

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Equipment

Facilities:                                                                               

Basic molecular biology and biomechanics laboratory (E)

Small animal laboratory (access via ZFE)

Large animal laboratory (access via ZFE)

Study Coordination (E)

Biomaterial bank (access to central biobank in cooperation)

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Methods

Methods 1 

  • Cell culture (E)
  • Flow cytometer (E)

Methods 2                  

  • Quantitative PCR (E)
  • ELISA (E)
  • Western blot (E)
  • Immunohistochemistry (E)
  • Microscopy (E)
  • Genetic analyses (in collaboration with other departments)
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Staff

  • 5 doctors with research projects                               
  • 1 teaching assistant
  • 6 PhD students
  • 1 Master’s student
  • 1 scientist

Research focus areas

Key research areas:

Aortic surgery, aortic biomechanics, miRNA expression in AAA, markers for vascular diseases, PAD, healthcare research, wound research

Clinical projects:

  • ENCHANT: Post-market study of the Endurant CHEVAR graft technique for the treatment of juxtarenal aortic aneurysms with a short infrarenal neck
  • AndraValvulotome Post-Market Study
  • ADVANCE: Global prospective randomised clinical trial in sac regression
  • HERCULES: Post-market, prospective, global, multicentre, randomised, two-arm, non-inferiority trial comparing ESAR to EVAR regarding clinical outcomes in patients with wide proximal aortic neck diameters

Other clinical projects:

  • New patient-specific prosthesis for the treatment of type I endoleakage
  • Risk factors for significant dilation of the distal landing zone following EVAR
  • Clinical evaluation of new 4D ultrasound techniques in the diagnosis of BAA
  • Biomechanics of BAA
  • Influence of anatomical conditions on intraoperative radiation exposure during EVAR
  • Compliance in EVAR follow-up care
  • Risk factors for the development of compartment syndrome following trauma

Translational projects:

  • The significance of miRNAs as markers in aortic surgery

Fundamentals:

  • Aortic biomechanics
  • Transcriptional and epigenetic markers in atherosclerosis

Contact person

Univ.-Prof. Dr. med. Kyriakos Oikonomou

Send email

Dr. med. Wojciech Derwich, MHBA

Send email

Collaborations

On campus:

  • Institute of Vascular Signalling, Centre for Molecular Medicine
  • Department of Trauma, Hand and Reconstructive Surgery

Interregional:             

  • Max Planck Institute, Bad Nauheim
  • Frankfurt University of Applied Sciences

Events and network

  • Weekly scientific team meetings
  • University Vascular Symposium twice a year
  • Interdisciplinary symposia and meetings (neurovascular, cardiovascular)

Publications

  • Current PhD theses: 6
  • Current Master’s theses: 1
  • Doctoral theses completed in the last 5 years (2017–2021): 7

 

Key publications by research staff

Prof. Kyriakos Oikonomou, MD:

https://pubmed.ncbi.nlm.nih.gov/?term=Oikonomou+K+vascular&sort=date&size=100

Dr Wojciech Derwich, MHBA:

https://pubmed.ncbi.nlm.nih.gov/?term=Derwich+W&sort=date&size=50

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