DGG Mannequin

Department of Vascular and Endovascular Surgery, University Hospital Münster

Research location

Department of Vascular and Endovascular Surgery, University Hospital Münster
Director: Professor Alexander Oberhuber, MD

Research

Clinical trials

“Vital” Clinical Trials Centre

Contact: Jana Ebing/Teresa Nierhoff

Laboratory for Vascular Biology

Clinical and Experimental Research and Biobank

Head: Dr. rer. nat. Thorsten Eierhoff

Septic Vascular Surgery Working Group

Head: Dr Abdulhakim Ibrahim

Endovascular Therapy Research Group

Head: Dr Elena Marchiori

Location
Albert-Schweitzer-Campus 1
48149 Münster

Icon Ausstattung

Equipment

  • Molecular Biology Laboratory (E)
  • Cell Culture Laboratory (E)
  • (Live-cell) fluorescence microscopy (E)
  • LC/MS analysis (K)
  • Microbiome sequencing (K)
  • TEER measurements using cellZscope (K)
  • Biobank (tissue, blood, stool) (E)
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Methods

  • Cell culture
  • Flow chamber analyses
  • Isolation and cultivation of primary cells from the vascular wall
  • Histology
  • Molecular biology methods (including Western blot, ELISA, PCR)
  • Microscopy (inverted and upright microscopes, fluorescence and live-cell microscopy)
  • Measurement of multi-well assays using a multimode plate reader
  • Measurement of endothelial permeability (under flow conditions):
    • TEER measurements
    • Dextran permeability assays
  • Collection of (multicentre) clinical-experimental data using RedCAP (in-house server)
  • Management of clinical samples using CentraXX
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Staff

  • Laboratory management
  • Working group leaders
  • TAs
  • Study Nurses
  • Medical PhD students
  • 12 investigators in accordance with the German Medicines Act (AMG) and Medical Devices Act (MPG), including the clinical trial director

Research focus areas

Clinical research

1. Focus on aortic diseases

  • Innovative methods of aortic management (aortic arch/thoracic/abdominal segment)
  • Outcomes following treatment of acute/subacute aortic dissections
  • Outcome following complex thoracoabdominal aortic treatment
  • Management of complex endoleaks following endovascular treatment
  • Dissections
  • Post-implantation syndrome (thoracic/thoracoabdominal)
  • Remodelling following endovascular aneurysm treatment/dissection
  • Perioperative management following complex aortic surgery
  • Risk factors for spinal ischaemia
  • Development of new stent grafts for the thoracoabdominal region
  • Prosthesis infections

2. Focus on imaging and radiation protection

  • Evaluation of microcirculation
  • 4D MRI and MRA following complex stent graft placement
  • IVUS-guided treatment of aortic conditions and PAD
  • The effect of ionising radiation on DNA double-strand breaks and senescence

3. Focus on conservative vascular medicine

  • The impact of structured walking training
  • Smoking cessation
  • Lipid therapy

4. National/international multicentre projects

  • CO2-EVAR
  • CONFORM TAA/TAD
  • CONNECT
  • EASY
  • EMINENT
  • Flowgraft
  • INNER-B
  • INSIGHT
  • Nephrocheck
  • PAPAartis
  • PERCEIVE
  • PLIANTII
  • POPART
  • PROMOTE-ALI
  • RbG Smoking Cessation Study
  • SOLARIS
  • STABILISE
  • Triple arch branch

Translational:

  • Endothelial markers in aortic pathologies

Background:       

  • Gut microbiome and arterial vascular diseases
  • Mechanisms of endothelial integrity in aortic pathologies
  • Cellular sensing and signal transduction of metabolites (including short-chain fatty acids)
  • Biobanking of vascular tissue, blood and stool samples

Contact person

Univ.-Prof. Dr. med. Alexander Oberhuber

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Dr. rer. nat. Thorsten Eierhoff

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Dr. med. Abdulhakim Ibrahim

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Dr. med. Elena Marchiori

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Collaborations

On campus:

  • Institute of Experimental Pathology
  • Department of Cardiothoracic Surgery
  • Institute of Inorganic and Analytical Chemistry
  • Institute of Musculoskeletal Medicine, Department of Translational Rheumatology and Immunology
  • Institute of Pharmaceutical Technology and Biopharmacy
  • Plastic Surgery
  • Central Biobank of the Faculty of Medicine, Münster (ZBB-MFM)
  • FSP ‘Vascular Systems’ of the Faculty of Medicine, Münster

Interregional:             

  • Düsseldorf University Hospital
  • Cologne University Hospital
  • Aachen University Hospital
  • Charité University Hospital Berlin
  • University of Freiburg
  • University of Hamburg
  • University of Strasbourg

Events and network

  • NRW Basic Research Meeting
  • Meeting: Interdisciplinary Diabetes Outpatient Clinic
  • GGWest
  • Member of the Network for Basic Research in Vascular Medicine

Publications

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