University Heart Center Freiburg

Clinical:                 

Heart valve surgery

1. TVR (tricuspid valve in MKE/MKR) CTSN/DZHK: Beyersdorf, Siepe, Bothe, Thoma, Czerny, Zimmer, Zeh, Scheumann, Ballazhi, Ayala, Pingpoh, Benk, Fagu, Diab, Seufert,
2. DEDICATE BK+FR (Surgical AKE vs. transfemoral/apical TAVI) DZHK: Beyersdorf, Schröfel, Bothe, Siepe, Czerny, Thoma, D. Schibilsky, Zimmer, Kueri, Al-Hamami, Pingpoh
3. INCA (Edwards Intuity + Bypass registry) IIT Diegeler BN: Zimmer, Siepe, Beyersdorf, Al-Hamami, Fagu, Pingpoh
4. INDURE (AKE with Inspiris Resilia) Industry: Siepe, Diab, Thoma, Zimmer, Fagu, Pingpoh, Kueri, Benk, Schröfel, Kreibich, D. Schibilsky
5. AcChord (MKR with NeoChord) Industry: Schröfel

Aortic surgery

1. GRIPFLOW (cerebral perfusion catheter for aortic arch surgery) Industry (in planning): Czerny
2. EXTEND (Thoraflex Hybrid and Relay Extension registry) Industry (in planning): Czerny
   FEVAR (covered BeGraft by Bentley) Industry: Czerny, Rylski, Kondov, Uzdenov, Al-Hamami
3. Dissect-N (Valiant Navion Thoracic Stent Graft Registry) Industry (in planning): Czerny, Rylski, Kondov
4. NIRT for aortic arch reconstruction (intraoperative stroke prevention) IIT: Kaller & Czerny, Ch. Benk, Maier
5. Panther(Cardiovascular Patches and Terumo Aortic Grafts registry) Industry: Czerny, Rylski, Kondov, Al-Hamami, Uzdenov, Liu, Chikvatia
6. PAPAartis (Prevention of Paraplegia in TAAA) IIT Leipzig EU Horizon 2020: Czerny, Beyersdorf, Rylski, Siepe, J. Benk, Kondov
7. TiGER (Register of Terumo aortic grafts in TEVAR, EVAR, FEVAR, IIAA) Industry: Rylski, Czerny, Kondov, Al-Hamami, Fagu, Chikvatia, Batinkov, Leinberger, Ahlbrecht, Bork, Scheumann, Discher, Batinkov
8. THOR (FET registry for TAA) Industry: Czerny, Siepe, Rylski, Beyersdorf, Bothe, Fagu, Zimmer, Al-Hamami, Benk, Fernandez, Ahlbrecht, Shahinian, Kreibich, Walter, Discher, Uzdenov, Scheumann, Kondov
9. EUREC (Register of Complications of Endovascular Thoracic and Abdominal Aortic Stent Implantation) IIT: Czerny, J. Benk
10. GEARR (David Registry) Heart Foundation: Kari, Beyersdorf, Siepe, Zimmer, Rylski, Scheumann, Czerny, Fernandez
11. 4D imaging + serum markers in aortic diseases. IIT: Czerny, Shahinian, Rylski, Beyersdorf, J. Benk, D`Inka, Ayala, Kondov, Demir, Kreibich, Discher, Walter, Berger, Al-Hamami, Bork

 Vascular Surgery

1. REX-SFA (Re-stenosis in PAD). (in planning) IIT Czerny, Zeller: Kerber
2. PESTO-AFC study (PTA vs. TEA for lesions of the common femoral artery). IIT Zeller: Czerny, Beyersdorf, Siepe, Pölsler
3. GermanVasc (PAVK registry) IIT: Czerny, Beyersdorf, Pölsler, Siepe, Schröfel, Thoma, Schöllhorn, Rylski, Kondov, Dimov, Al-Hamami, Zimmer, Fagu, Discher, Chikvatia, Bespayeva, B. Schibilsky

Coronary surgery 

1. Caiman (radial artery vs. open technique in aorto-coronary bypass surgery) IIT with industry sponsor (in planning): Fagu, Czerny, Berger, Pingpoh, Dimov, Kondov, Eschenhagen, D’Inka, Ballazhi, Siepe, Beyersdorf
2. ROMA (single vs. multiple arterial (r) graft(s) in coronary bypass surgery) Cornell University, New York: Czerny, Beyersdorf, Siepe, Kroll, Rylski, Dimov
3. Intraoperative quality control in coronary artery bypass surgery. IIT: Beyersdorf, Rylski, Kreibich, Demir, Chikvatia

Mechanical cardiac support, heart transplantation and intensive care medicine

1. CARMAT (TAH) Industry: D. Schibilsky, Beyersdorf
2. OCS (in heart transplantation): Beyersdorf, Siepe, Berchtold-Herz, Schibilsky, Kroll, Rylski, Czerny, Benk
3. VAD Study (Early VAD vs. Standard) DZHKF/BMBF: Beyersdorf, Siepe, Berchtold-Herz, Schibilsky, D’Inka, Ballazhi
4. Re-Elevate (HeartMate III Register) Industry: Beyersdorf, Berchtold-Herz, Schibilsky, Ayala, Scheumann, Kondov, Benk, Demir
5. Haemostasis in HTX, VAD, ECLS, ECMO: Zieger & Geisen & Berchtold-Herz, Trummer, Pernice, Pooth
6. Controlled whole-body reperfusion: Beyersdorf, Trummer, Benk, Damjanovic, Pooth, Brixius, Scherer

Paediatric cardiac surgery and surgery for congenital heart defects

1. Congenital Heart Defects Registry (Complex Transposition of the Great Arteries) National Quality Assurance: Kari

Other studies

1. ASOLO-SW (Avance Solo NPWT system for exuding wounds) Industry (in planning): Czerny
2. DefiPace (pacemaker for intraoperative cardiac arrhythmias) IIT + Industry + EU Horizon 2020 (in planning): Ballazhi, Eschenhagen, et al.
3. ITACS (Intravenous iron for pre-operative anaemia) University Hospital Bonn (in planning): Schibilsky, Fernandez
4. Freiburg Resuscitation Registry (survival following cardiac arrest): Trummer, Pooth, Brixius, Steger, Busch, Schmid

Translational:

1. Aortic Medicine Working Group, Prof. Dr Martin Czerny
2. YCOR – Heart adapter for minimally invasive artificial heart implantation, Dr Bothe
3. GEARR – German Aortic Root Repair Registry, Dr Fabian Kari
4. ResuSciTec – Controlled reperfusion following cardiac arrest, Prof. Dr Georg Trummer, Prof. Dr Friedhelm Beyersdorf
5. ResuSciTec – Priming evaluation, Prof. Dr Georg Trummer, Prof. Dr Friedhelm Beyersdorf
6. Biomarkers for shear stress and wall tension in thoracic aortic aneurysms, PD Dr Fabian Kari
7. Development of techniques for endo-conduit implantation, Prof. Dr Bartosz Rylski
8. Spinal ischaemia in aortic arch replacement and thoracoabdominal aortic surgery, PD Dr Fabian Kari
9. Proteome biology of the myocardium and pathological changes, Prof. Dr Matthias Siepe
10. Automated Controlled Ex-Vivo Normothermic Perfusion (ac-EVP) of the Heart and Organ Protection by Carbon Monoxide Application (NORMAN E. SHUMWAY CAREER DEVELOPMENT AWARD 2018, ISHLT), Dr David Schibilsk
11. Cardiovascular Biobank (CVBB), sub-project leader PD Dr Fabian Kari (project lead Prof. Dr Kohl, IEKM
12. REA-Mobil – Prof. Dr Georg Trummer
13. HTX and organ protection, Dr David Schibilsk
14. Interaction between endoconduit and native aortic root, Prof. Dr Czerny, Prof. Dr Trummer, Prof. Dr Beyersdorf, Dr Shahinian, Prof. Dr Schilling, Russe, Prof. Dr Hilgendorf
15. Aortic surgery – optimisation of treatment methods, Prof. Dr Czerny, Prof. Dr Rylski, Dr Kondov, Dr Kari, Dr Kreibich, Dr Shahinian

Fundamentals:                      

1. INVEKZ – In vitro measurements in pump systems for extracorporeal circulation with altered whole blood viscosity, Prof. Dr.-Ing. Christoph Benk
2. Measurement of oxidative stress and antioxidants – OXEK (erythrocyte concentrates), Dr Jan-Steffen Pooth
3. Measurement of oxidative stress and antioxidants – ZIROX (circadian rhythm), Dr Jan-Steffen Pooth
4. Measurement of oxidative stress and antioxidants – BESTOX (perioperative oxidative stress), Dr Katharina Pernice
5. Measurement of oxidative stress and antioxidants – ALLOX (cross-sectional study), Dr Katharina Pernice

MeSH (Medical Subject Headings) 

1. Aortic Disease
2. Cardiovascular Diseases
3. Extracorporeal Membrane Oxygenation
4. Carotid Artery Disease
5. Ischaemia
6. Reperfusion
7. Proteomics
8. Vascular replacement with bovine pericardium