DGG Mannequin

Department of Visceral, Vascular and Endocrine Surgery – University Hospital Halle (Saale)

Research location

Department of Visceral, Vascular and Endocrine Surgery – University Hospital Halle (Saale)

Research

Dr Jörg Ukkat, Head of Vascular Surgery

PD Dr B. Trojanowicz, Research Coordinator and Head of the Molecular Medicine Laboratory

Location
Ernst-Grube-Straße 40
06120 Halle

Icon Ausstattung

Equipment

  • Basic Research Laboratory, Molecular Biology
  • Biomaterial bank: Tissues and sera
  • Cell lines

The Molecular Medicine Research Group has access to:
qPCR and Western blot platforms including a gel imaging system, conventional and fluorescence-based microscopy, a cryostat and microtome for immunohistological analysis, automated tissue dissociation for cell culture, and other techniques (e.g. FACS, conventional cell culture laboratory, ELISA reader).

The group has access to the hospital’s internal core facility for analysis, flow cytometry, imaging and animal husbandry.

https://www.medizin.uni-halle.de/einrichtungen/zentren/zentrum-fuer-medizinische-grundlagenforschung-zmg/leistungsspektrum/core-facilities

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Staff

  • 2 doctors with research projects
  • 2 Tas
  • 1 PhD student
  • 1 scientist

Research focus areas

Basics:

  • Markers of calcification on leukocytes, the vascular wall and in circulating blood
  • Molecular mechanisms of calcification in vitro

Contact person

Dr. med. Jörg Ukkat

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PD Dr. B. Trojanowicz

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Publications

  • Ukkat J, Rebelo A, Trojanowicz B
    Angiogenic transcriptional profiling reveals potential targets modulated in the blood of patients with cardiovascular disorders
    Vascular 2021; Vol. (0)0 1–11
  • Ukkat J, Hoang-Vu C, Trojanowicz B, Rebelo A
    Osteocalcin, osteopontin and RUNX2 expression in patients with arteriosclerosis
    W Academy of Sciences J 2021 Mar 12; 9(1):19, doi.org/10.3892/wasj.2021.103
  • Narayan SS, Lorenz K, Ukkat J, Hoang-Vu C, Trojanowicz B
    Angiotensin-converting enzymes ACE and ACE2 in thyroid cancer progression
    Neoplasma 2020; 67: 402–409
  • Ulrich C, Wildgrube S, Fiedler R, Seibert E, Kneser L, Fick S, Schäfer C, Markau S, Trojanowicz B, Girndt M.
    NLRP3 inflammasome activation in haemodialysis and hypertensive patients with intact kidney function. Toxins (Basel). 26 October 2020;12(11):E67
  • Matthias Girndt, Bogusz Trojanowicz, Christof Ulrich.
    Monocytes in Uraemia. Toxins (Basel) May 2020; 12(5): 340
  • Trojanowicz B, Imdahl T, Ulrich C, Fiedler R, Girndt M.
    Circulating miR-421 targeting leucocytic angiotensin-converting enzyme 2 is elevated in patients with chronic kidney disease. Nephron. 2019;141(1):61-74
  • Trojanowicz B, Ulrich C, Fiedler R, Martus P, Storr M, Boehler T, Werner K, Hulko M, Zickler D, Willy K, Schindler R, Girndt M.
    Modulation of leucocytic angiotensin-converting enzyme expression in patients maintained on high-permeability haemodialysis. Nephrol Dial Transplant. 2017 gfx206
  • Trojanowicz B, Ulrich C, Kohler F, Bode V, Seibert E, Fiedler R, Girndt M.
    Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease. Nephrol Dial Transplant. 1 February 2017;32(2):287-29
  • Ulrich C, Trojanowicz B, Fiedler R, Kohler F, Wolf AF, Seibert E, Girndt M.
    Differential Expression of Lipoprotein-Associated Phospholipase A2 in Monocyte Subsets: Impact of Uraemia and Atherosclerosis. Nephron. 2017;135(3):231-241
  • Trojanowicz B, Ulrich C, Fiedler R, Storr M, Boehler T, Martus P, Pawlak M, Glomb MA, Henning C, Templin M, Werner K, Zickler D, Willy K, Schindler R, Girndt M.
    Impact of serum and dialysates obtained from chronic haemodialysis patients maintained on high-cut-off membranes on the inflammatory profile in human THP-1 monocytes. Hemodial Int. 26 September 2016
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