DGG Mannequin

Department of Cardiovascular Surgery, University Medical Centre Schleswig-Holstein, Kiel Campus

Research location

Department of Cardiovascular Surgery, University Medical Centre Schleswig-Holstein, Kiel Campus
Head of the Clinic: Professor Jochen Cremer

Research

Department of Cardiovascular Surgery, University Medical Centre Schleswig-Holstein, Kiel Campus

Department of Vascular and Endovascular Surgery

Head of the Research Programme

  • Contact: Professor Jochen Cremer (Head of Department),
  • PD Dr Rouven Berndt (Vascular Medicine Research)

Location
Arnold-Heller-Straße 3
24105 Kiel

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Equipment

  • Basic Research Laboratory: Molecular Biology and Biomechanics
  • Small animal laboratory
  • Large Animal Facility
  • Clinical Trials Centre
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Methods

Methods 1

  • Cell culture (E)
  • REM (K)
  • Cell processing unit (Prodigy)/cleanroom (E)
  • Ischemia chamber (E)
  • Histology laboratory (E)
  • Laser speckle (E)
  • FACS (E)
  • Mechanical test bench (E)
  • Flow models (E)
  • RT-PCR (E)
  • Bioreactor (E)
  • 3D bioprinter (E)

Methods 2

  • Cell culture (E)
  • Cell processing unit (Prodigy)/Cleanroom (E)
  • Ischemia chamber (E)
  • Histology laboratory (E)
  • Laser speckle (E)
  • FACS (E)
  • Mechanical test bench (E)
  • Flow models (E)
  • RT-PCR (E)
  • Bioreactor (E)
  • 3D bioprinter (E)

 

* (E) = in-house, (K) = in cooperation

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Staff

  • 4 doctors with research projects
  • 4 PhD students
  • 3 PhD students
  • 2 PhD students
  • 3 scientists

Research focus areas

  1. Ischaemia/reperfusion
  2. Arteriogenesis and angiogenesis
  3. Aortic surgery and endovascular device performance
  4. Advanced Therapy Medicinal Products (ATMPs) and Bioengineering for Cardiovascular Diseases

Clinical

  • Establishment of a long-term protocol for the application of remote ischaemic  
  • Preconditioning (RIPC) in patients with PAD   
  • Prospective study on hybrid therapy in thoracoabdominal aortic surgery Establishment of minimally invasive (robot-assisted) methods in aortic surgery

Translational

  • Phase I study to establish a cell therapy for stage IV PAD   
  • 3D bioprinting and bioengineering of bioartificial cardiovascular implants

 

Fundamentals

Effects of the monocyte-macrophage axis on post-ischaemic remodelling in cardiovascular tissue

Contact person

PD Dr. Rouven Berndt

Send email

Collaborations

On Campus:

Department of Anaesthesiology, Institute of Pathology, Institute of Applied Cell Therapy, Faculty of Science and Engineering at Christian-Albrechts-Universität

Interregional: 

There are a number of project-related collaborations at international level (project-driven demand)   

Events and network

Life Science North Programme

Publications

2 Ongoing PhD theses

6 completed doctoral theses from the last 5 years (2017–2021)

3 Habilitations completed in the last 10 years (2012–2021)

 

2022

Rusch, R., Hoffmann, G., Cremer, J., & Berndt, R. (2022). Repair of the descending thoracic aorta using minimally invasive endoscopic robot-assisted surgery: a feasibility study with the DaVinci XI system in a cadaver model. European Journal of Cardio-Thoracic Surgery, 61(6), 1440–1442.

2021

Hummitzsch, L., Zitta, K., Fritze, L., Monnens, J., Vollertsen, P., Lindner, M., ... & Albrecht, M. (2021). Effects of remote ischaemic preconditioning (RIPC) and chronic remote ischaemic preconditioning (cRIPC) on levels of plasma cytokines, cell surface characteristics of monocytes and in vitro angiogenesis: a pilot study. Basic Research in Cardiology, 116(1), 1–16.

Berndt, R., Albrecht, M., & Rusch, R. (2021). Strategies to Overcome the Barrier of Ischemic Microenvironment in Cell Therapy of Cardiovascular Disease. International Journal of Molecular Sciences, 22(5), 2312.

2020

Hummitzsch, L., Albrecht, M., Zitta, K., Hess, K., Parczany, K., Rusch, R., ... & Berndt, R. (2020). Human monocytes subjected to ischaemia/reperfusion inhibit angiogenesis and wound healing in vitro. Cell proliferation, 53(2), e12753.

Rusch, R., Trentmann, J., Hummitzsch, L., Rusch, M., Aludin, S., Haneya, A., ... & Berndt, R. (2020). Effectiveness and safety of percutaneous thrombectomy devices: comparison of Rotarex and Angiojet in a physiological circulation model. European Journal of Vascular and Endovascular Surgery, 59(6), 983–989.

Salem, M., Friedrich, C., Rusch, R., Frank, D., Hoffmann, G., Lutter, G., ... & Puehler, T. (2020). Is total arch replacement associated with an increased risk after acute type A dissection?. Journal of Thoracic Disease, 12(10), 5517.

Wong, Y. L., Hummitzsch, L., Lautenschläger, I., Zitta, K., Wedel, T., Cossais, F., ... & Albrecht, M. (2020). Putative function of goblet cells as epithelial sealing in ischaemia/reperfusion-induced intestinal barrier dysfunction. Gut, 69(10), 1888–1890.

2019

Rusch, R., Trentmann, J., Hummitzsch, L., Rusch, M., Aludin, S., Haneya, A., ... & Berndt, R. (2019). Feasibility of a circulation model for the assessment of endovascular recanalisation procedures and periprocedural thromboembolism in vitro. Scientific Reports, 9(1), 1–6.

2018

Berndt, R., Hummitzsch, L., Heß, K., Albrecht, M., Zitta, K., Rusch, R., ... & Groß, J. (2018). Allogeneic transplantation of programmable cells of monocytic origin (PCMO) improves angiogenesis and tissue recovery in critical limb ischaemia (CLI): a translational approach. Stem Cell Research & Therapy, 9(1), 1–17.

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